On television, he played Tom Ferguson in the long-running soap Coronation Street (1999–2000), Ivor Claire in the Evelyn Waugh adaptation Sword of Honour (2001), Stephen Clarke in the thriller Suspicion (2003) and Marco Bailey in Sky One's airline drama Mile High (2003–2004).
Other television work includes Harry Enfield's Brand Spanking New Show, Children of the New Forest, Wycliffe and Blackhearts in Battersea. In early 2010 Tom starred in an episode of Agatha Christie's Poirot. Wisdom's theatre roles include Stanhope in Journey's End (UK tour, 2005) and Guy Bennett in Julian Mitchell's Another Country (Arts Theatre, 2000).
Wisdom created the role of Steven Carter in Patrick Wilde's play What's Wrong With Angry? in 1994.
His films include The Boat That Rocked which was released in the UK on 1 April 2009, The Sisterhood of the Traveling Pants 2 which was released on August 8, 2008 (US), and Fire and Ice, which was released in Romania in September 2008 and in the US in November 2008 on the Sci-Fi channel.
He will also be appearing in the 2013 film Romeo and Juliet alongside other hot actors like Christian Cooke.